Infection with Canine Distemper Virus Morbid Obesity Induced in Mice by Brain Alteration of the Leptin Network in Late
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Alteration of the leptin network in late morbid obesity induced in mice by brain infection with canine distemper virus.
Viruses can induce progressive neurologic disorders associated with diverse pathological manifestations, and therefore, viral infection of the brain can impair differentiated neural functions, depending on the initial viral tropism. We have previously reported that canine distemper virus (CDV) targets certain mouse brain structures, including the hypothalamus, early and selectively. Infected mi...
متن کاملIdentification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity.
Obesity results from disturbances of tightly regulated interactions between the nervous, endocrine, and metabolic systems that can be caused by external factors, such as viral infections. A mouse model of obesity induced by brain infection with a morbillivirus, canine distemper virus, allowed us to identify obesity-related genes. Using a subtractive library for the hypothalamus, the main brain ...
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Background and Objective: Canine distemper (CD) is a highly transmissible serious disease of carnivores. Distemper virus has immunosuppression effects, which, in turn, could lead to opportunistic infections. The present study was performed to detect CDV by the genomic and immunological methods and investigate its co- infection with canine parainfluenza virus type 2 (CPiV-2). Materials and Meth...
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Background and Aims: Canine distemper (CD) is a deadly infectious disease of Canidae family. CD is a multi-systemic viral disease and is specified by wide range of clinical symptoms. The manifestations are not always indicative of CD, therefore a laboratory confirmation is necessary for suspected cases. Materials and Methods: Different clinical specimens of 19 CD suspected unvaccinated dogs wer...
متن کاملRelation between Obesity and Ghrelin, Leptin Hormones, Vitamin D and Viruses
Obesity, also named as New World Syndrome, is emerging as a frequent global health issue with increasing incidence rate and exercise influence over the world. Recent researches have shown that obesity was associated with levels of ghrelin and leptin hormones, vitamin D deficiency, SMAM-1 avian adenovirus, Canine distemper virus (CDV), Rous-associated virus-7 (RAV-7), Borna disease virus (BDV), ...
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تاریخ انتشار 1999